Inhibitory effect of anti-mouse egg serum on fertilization in vitro and in vivo in the mouse

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Abstract
It has been reported that heteroimmune anti-ovary serum can block sperm penetration of the zona pellucida in vitro in hamsters (Shivers, Dudkiewicz, Franklin & Fussell, 1972; Oikawa & Yanagimachi, 1975; Tsunoda & Chang, 1976a), mice (Jilek & Pavlok, 1975) and rats (Tsunoda & Chang, 1976b). Passive immunization with anti-ovary serum can also prevent fertilization in vivo in hamsters (Oikawa & Yanagimachi, 1975; Tsunoda & Chang, 1976d), mice (Jilek & Pavlok, 1975; Tsunoda & Chang, 1976d) and rats (Tsunoda & Chang, 1976d). Inhibition of pregnancy by isoimmunization with ovarian extracts has been observed in guinea-pigs (Porter, 1965) and mice (Tsunoda & Chang, 1976c). It therefore seems possible that inhibition of fertilization by anti-ovary serum is caused by a zona pellucida-specific antigen(s) which is derived from the ovary. I therefore examined the effect of an antiserum against mouse eggs on fertilization in mice.