Growth Hormone Signal Transduction
- 1 January 2002
- journal article
- review article
- Published by Walter de Gruyter GmbH in Journal of Pediatric Endocrinology and Metabolism
- Vol. 15 (6) , 771-786
- https://doi.org/10.1515/jpem.2002.15.6.771
Abstract
Multiple signaling pathways mediate the diverse effects of growth hormone (GH) on growth and metabolism. The interaction of GH with GH receptors (GHR) on target cells promotes the association of the cellular tyrosine kinase JAK2 with the GHR, initiating tyrosine phosphorylation of GHR and JAK2, and activation of multiple signaling cascades. GH-stimulated activation of signal transducers and activators of transcription (STATs), mitogen activated protein kinase (MAPK) and phosphatidylinositol 3' kinase (PI3K) cascades have been shown to regulate the transcription of GH-responsive genes. Cross-talk among these signaling cascades in regulating specific genes suggests that GH signaling to the nucleus involves a GH-regulated signaling network.Keywords
This publication has 99 references indexed in Scilit:
- The Signal Transduction of the Growth Hormone Receptor Is Regulated by the Ubiquitin/Proteasome System and Continues After EndocytosisJournal of Biological Chemistry, 2001
- Growth Hormone, Interferon-γ, and Leukemia Inhibitory Factor Utilize Insulin Receptor Substrate-2 in Intracellular SignalingPublished by Elsevier ,1996
- The membrane proximal region of the cytoplasmic domain of the growth hormone receptor is involved in the activation of Stat 3FEBS Letters, 1995
- Studies with Wortmannin Suggest a Role for Phosphatidylinositol 3-Kinase in the Activation of Glycogen Synthase and Mitogen-Activated Protein Kinase by Insulin in Rat Adipocytes: Comparison of Insulin and Protein Kinase C ModulatorsBiochemical and Biophysical Research Communications, 1995
- PI-3-Kinase Inhibitor Wortmannin Blocks the Insulin-Like Effects of Growth Hormone in Isolated Rat AdipocytesBiochemical and Biophysical Research Communications, 1994
- Simultaneous Activation of p90rsk and p70s6k S6 Kinases by Growth Hormone in 3T3-F442A PreadipocytesBiochemical and Biophysical Research Communications, 1993
- Regulation of two rat serine‐protease inhibitor gene promoters by somatotropin and glucocorticoidsEuropean Journal of Biochemistry, 1992
- Intracellular processing of growth hormone receptors by adipocytes in primary cultureMolecular and Cellular Endocrinology, 1988
- Growth hormone promoted tyrosyl phosphorylation of growth hormone receptors in murine 3T3-F442A fibroblasts and adipocytesBiochemistry, 1988
- Role of kinase C in the insulin-like effects of human growth hormone in rat adipocytesBiochemical and Biophysical Research Communications, 1987