AN IMPROVED METHOD TO STUDY ANTI-BACTERIAL ACTIVITY OF ANTIBIOTICS IN AN INVITRO MODEL SIMULATING SERUM LEVELS

  • 1 January 1980
    • journal article
    • research article
    • Vol. 2  (4) , 171-176
Abstract
The bacterial activity of cefoxitin was studied in an improved in vitro model simulating [human] serum levels. The peak concentration of cefoxitin was 110 .mu.g/ml as achieved after 1 g i.v. Half-life time was adjusted to 50 min. The time at which the viable count reached the mark 1% of the original inoculum after the lowest count was determined (regrowth period) was 1-10 h from the beginning of the experiments.

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