Potentiation of the Effect of Orally Administered Anticoagulants by Phenyramidol Hydrochloride

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Abstract
IT is well known that administration of one drug may inhibit or potentiate the effect of another.1 Such an interaction is of particular clinical importance when anticoagulants are given, because its recognition may prevent serious hemorrhagic complications and may result in a smoother control of the prothrombin time. This report deals with the effect of phenyramidol hydrochloride (Analexin) on the response to orally administered anticoagulants. To my knowledge this is the first report on this action of phenyramidol.Phenyramidol is a 2-(beta-hydroxyphenethylamino)-pyridine hydrochloride marketed for use in acute and chronic conditions in which both muscle spasm and pain are involved. . . .