Biochemical activities of the derivatives of dehydrodicaffeic acid dilactone.
- 1 January 1978
- journal article
- research article
- Published by Japan Antibiotics Research Association in The Journal of Antibiotics
- Vol. 31 (2) , 105-111
- https://doi.org/10.7164/antibiotics.31.105
Abstract
Activities of derivatives of dehydrodicaffeic acid dilactone (DDCAD) to inhibit [rat, mouse liver] catechol-O-methyltransferase (COMT), [rat brain] cyclic AMP phosphodiesterase (PDE) and dopa decarboxylase (DDC) were examined. Among those tested, 2,6-bis-(5'',6''-dibromo-4''-hydroxy-3''-methoxyphenyl)-3,7-dioxabicyclo-[3,3,0]-octane 4,8-dione was the strongest inhibitor of both COMT and PDE. There were no derivatives which showed a stronger inhibition against DDC than the original compound, DDCAD.This publication has 4 references indexed in Scilit:
- Purification and Properties of a Dehyrodicaffeic Acid Dilactone-forming Enzyme from a Mushroom,Inonotussp. K-1410Agricultural and Biological Chemistry, 1977
- Dehydrodicaffeic acid dilactone, an inhibitor of catechol-O-methyl transferase.The Journal of Antibiotics, 1976
- Reticulol, an inhibitor of cyclic adenosine 3',5'-monophosphate phosphodiesterase.The Journal of Antibiotics, 1975
- Enzymatic O-Methylation of Epinephrine and Other CatecholsJournal of Biological Chemistry, 1958