Recombinant interleukin 4 suppresses the production of interferon gamma by human mononuclear cells.
Open Access
- 1 November 1989
- journal article
- research article
- Published by Rockefeller University Press in The Journal of Experimental Medicine
- Vol. 170 (5) , 1751-1756
- https://doi.org/10.1084/jem.170.5.1751
Abstract
RIL-4 inhibits the production of IFN-gamma by PBMC stimulated with mitogens or allogeneic cells. The suppression is observed at the protein and at the mRNA level; it is dose and time dependent, and it is abolished by a neutralizing mAb to IL-4. It is suggested that the balance between the production of IL-4 and IFN-gamma may be significantly influenced by the chronological order of activation of their respective gene.This publication has 15 references indexed in Scilit:
- Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets.The Journal of Experimental Medicine, 1989
- IFN-gamma regulates the isotypes of Ig secreted during in vivo humoral immune responses.The Journal of Immunology, 1988
- Regulation of cytolytic cell populations from human peripheral blood by B cell stimulatory factor 1 (interleukin 4).The Journal of Experimental Medicine, 1987
- Interferon-γ and B Cell Stimulatory Factor-1 Reciprocally Regulate Ig Isotype ProductionScience, 1987
- Regulation of IFN-gamma induction in human peripheral blood cells by exogenous and endogenously produced interleukin 2.The Journal of Immunology, 1985
- INVITRO SYNTHESIS OF IGE BY HUMAN-LYMPHOCYTES .2. ENHANCEMENT OF THE SPONTANEOUS IGE SYNTHESIS BY IGE-BINDING FACTORS SECRETED BY RPMI-8866 LYMPHOBLASTOID B-CELLS1984
- Killing of intracellular Leishmania donovani by lymphokine-stimulated human mononuclear phagocytes. Evidence that interferon-gamma is the activating lymphokine.Journal of Clinical Investigation, 1983
- Identification of interferon-gamma as the lymphokine that activates human macrophage oxidative metabolism and antimicrobial activity.The Journal of Experimental Medicine, 1983
- [18] Hybridization of denatured RNA transferred or dotted to nitrocellulose paperPublished by Elsevier ,1983
- Isolation of biologically active ribonucleic acid from sources enriched in ribonucleaseBiochemistry, 1979