Synthesis and antitumor activity of seleno- and thio-purines complexed with cis-diamminoplatinum (II)

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Abstract
Cis-Diamminoplatinum (II) complexes with selenoguanine, thioguanine, 6-thioxanthine or 6-mercaptopurine were synthesized by the reaction of stoichiometric amounts of selenopurine or thiopurine with aquated cis-dichlorodimmineplatinum (II) in slightly acidic medium. Their antitumor activity was studied against [mouse leukemia] L1210 cells in mice. These compounds exhibited a medium antitumor activity with very low toxicity. The antitumor activity was dependent on the nature of the purine ligand. These complexes were very stable in various aqueous solvents at 37.degree. C for 10 days, but not in the presence of mouse serum. The mechanism of the action effected by the complex is not clear. The slow release of an antitumor active purine from the complex, SeG-Pt (NH3)2, was observed.