2-Benzodioxinylaminoethanol: a new class of .beta.-adrenergic blocking and antihypertensive agents
- 1 August 1981
- journal article
- research article
- Published by American Chemical Society (ACS) in Journal of Medicinal Chemistry
- Vol. 24 (8) , 994-998
- https://doi.org/10.1021/jm00140a015
Abstract
Various 2-benzodioxinylaminoethanol derivatives were synthetized and investigated for .beta.-adrenergic blocking activity. Most compounds demonstrated a .beta.-blocking activity of a competitive type when evaluated in guinea pig atrial and tracheal preparations. Three compounds were more potent than practolol and propranolol. All compounds demonstrated antihypertensive properties in spontaneously hypertensive rats. The most active compound was 1-(1,4-benzodioxin-2-yl)-2-[N4-(2-methoxyphenyl)piperazino]ethanol, which at 2.5 mg/kg i.v. lowered blood pressure by 41%.This publication has 8 references indexed in Scilit:
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