THE NATURE OF THE PROSTAGLANDIN-PRODUCING MONONUCLEAR CELL IN HUMAN PERIPHERAL-BLOOD

  • 1 January 1981
    • journal article
    • research article
    • Vol. 97  (2) , 179-186
Abstract
The human peripheral mononuclear cell responsible for PG[prostaglandin]E production was identified. The PG-producing cell was glass adherent, was removed by techniques that effectively removed phagocytic cells (carbonyl iron) and was not an E-rosette cell. The peripheral mononuclear cells that contain cytoplasmic PGE by indirect immunofluorescence also ingest latex particles. B and T lymphoid cell lines did not produce large quantities of PGE. Mononuclear cells separated on discontinuous bovine serum albumin gradients varied greatly in their ability to produce PG (low density > high density). The majority of PGE produced in peripheral mononuclear cell suspensions apparently emanates from a population of low-density monocytes.