Leukemogenesis by Gross passage A murine leukemia virus: expression of viruses with recombinant env genes in transformed cells.

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Abstract
Gross passage A murine leukemia virus (MuLV) derived from extracts of C3Hf/Bi mouse leukemias was shown to be a virus complex consisting of ecotropic, xenotropic, and recombinant, dualtropic MuLV components. The 3 virus components were distinguished biochemically by differences in the MW and peptide maps of their primary env gene products synthesized in infected mouse cells in vivo and in vitro. Virus expression was studied in primary leukemias induced in C3Hf/Bi mice by Gross passage A virus extracts and by the individual ecotropic and recombinant MuLV components that were isolated in vitro. Expression of the recombinant MuLV component of the Gross passage A virus complex apparently is necessary and sufficient for the induction of leukemias in C3Hf/Bi mice. Induction of leukemias by the ecotropic virus component appears to involve generation of a 2nd virus with characteristics of recombinant, dualtropic MuLV.

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