Spatial clustering of hemorrhages in probable cerebral amyloid angiopathy
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- 1 September 2005
- journal article
- research article
- Published by Wiley in Annals of Neurology
- Vol. 58 (3) , 459-462
- https://doi.org/10.1002/ana.20596
Abstract
Cerebral amyloid angiopathy (CAA) is a common cause of symptomatic intracerebral hemorrhage (ICH), as well as small asymptomatic hemorrhage in the elderly. We used gradient‐echo MRI to analyze spatial distribution of 321 hemorrhages in 59 patients with probable CAA–related ICH. Hemorrhagic lesions were found preferentially in the temporal (ratio of actual to expected hemorrhages = 1.37) and occipital lobes (ratio = 1.45, p < 0.0001). Within individuals, hemorrhages tended to cluster, regardless of lobe (p < 0.0001). Among subjects followed prospectively for recurrence, clustering of new symptomatic and asymptomatic hemorrhages was observed. These data suggest that regional differences within the brain play a role in the development of CAA–related hemorrhage. Ann Neurol 2005;58:459–462Keywords
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