Acute Yellow Atrophy Following Cinchophen Administration

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Abstract
ABOUT twenty years ago Cabot1 first reported a case of acute yellow atrophy allegedly due to cinchophen. Although similar cases have been recognized since that time, clinicians who use cinchophen with no observed untoward effects have minimized it as a hepatotoxic agent. One series has been reported, for example, in which cinchophen was given to 2500 patients without a fatal case.2 The toxic manifestations of cinchophen against which the physician is usually cautioned are chiefly those of the skin. Among them, urticaria and the erythematous morbilliform rashes are said to be most frequently encountered. But perhaps more important are signs . . .

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