Effect of tetracycline on gingival inflammation and alveolar bone resorption n beagles: An individual tooth by tooth analysis

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Abstract
The effect of systemic tetracycline on gingival inflammation and alveolar bone resorption was studied in beagle dogs. Seventeen dogs were divided into 3 groups receiving either no treatment, 250 mg tetracycline HCl or 500 mg tetracycline HCl daily. The severity of gingival inflammation and activity of alveolar bone resorption during a 6-mo. pretreatment period was compared to a 24-mo. treatment period for each individual tooth studied. In the 1st 12 months of treatment there was a significant decrease in the severity of gingival inflammation and the activity of alveolar bone loss in the tetracycline treated dogs. By 24 mo. of treatment, increased gingival inflammation and rate of bone loss was evident in the treated dogs. In the untreated control dogs there was a statistically significant association between the severity of gingival inflammation and activity of alveolar bone resorption about the teeth studied. In the tetracycline treated dogs, no such association existed.