Antiviral activity of primate γδ T lymphocytes isolated by magnetic cell sorting
- 5 February 1994
- journal article
- clinical trial
- Published by Wiley in Journal of Medical Primatology
- Vol. 23 (2-3) , 131-135
- https://doi.org/10.1111/j.1600-0684.1994.tb00113.x
Abstract
The exposure of human or rhesus monkey peripheral blood mononuclear cells (PBMCs) to interleukin 2 (IL‐2) in vitro resulted in a selective outgrowth of γδ lymphocytes. Using positive selection by monoclonal antibodies and magnetic beads, γδ T lymphocytes were isolated from these cultures. Without priming by viral antigens, the purified γδ T lymphocytes lyse immunodeficiency virus‐infected cells substantially better than the uninfected counterparts.Keywords
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