RELATIONSHIPS AMONG DIGITAL CLUBBING, DISEASE SEVERITY, AND SERUM PROSTAGLANDINS F-ALPHA AND E CONCENTRATIONS IN CYSTIC-FIBROSIS PATIENTS

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Abstract
Nine patients with cystic fibrosis but without digital clubbing (Group A) were matched, prospectively, by sex and approximate age to 9 cystic fibrosis patients with digital clubbing (Group B) and to 9 normal persons (control subjects). Patients in Group B had significantly (P < 0.05) lower clinical scores and forced vital capacity than did those in Group A, indicating more severe pulmonary disease in the former; however, other spirometer tests of pulmonary function revealed no differences between Groups A and B. The degree of digital clubbing had significant (P < 0.05) linear relationships to forced vital capacity (r = -0.73) and clinical scores (r = 0.853) for Groups A and B. Plasma concentrations of prostaglandins F2.alpha. and E were significantly increased (P < 0.05) in both Group A (.hivin.X .+-. SE, 0.48 .+-. 0.03 and 0.87 .+-. 0.10 ng/ml, respectively) and Group B (.hivin.X .+-. SE, 0.68 .+-. 0.04 and 1.81 .+-. 0.16 ng/ml, respectively) compared to the control group (.hivin.X .+-. SE, 0.14 .+-. 0.01 and 0.39 .+-. 0.02 ng/ml, respectively). Group B had significantly larger concentrations than did Group A; however, plasma concentrations of prostaglandin 15-keto-13, 14-dihydro metabolite were not different in Groups A and B, and were significantly smaller than in the control group. The degree of digital clubbing in cystic fibrosis is related to the severity of the pulmonary involvement and the PG system may play an important role in this disease.