Furosemide, a new diuretic in edematous states. Clinical studies in patients with congestive heart failure and cirrhosis of the liver

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Abstract
Furosemide was studied in 17 patients with severe fluid retention, 8 with congestive heart failure and 9 with cirrhosis of the liver with ascites. A good diuretic response was obtained with the oral and the parenteral preparations in 15 to 17 patients. Water and Na excretion increased markedly with only a small increase in K excretion and no significant change in serum electrolytes. Patients were severe cirrhosis of the liver may develop marked hypokalemia with a dosage higher than 120 mg daily. No abnormalities were found in blood counts, blood sugar, and liver function tests in either the acute or long-term studies. Mild asymptomatic hyperuricemia occurred in 6 patients. No significant side effects occurred. Furosemide is a safe, potent, rapidly-acting diuretic, and a promising adjunct in the treatment of patients with fluid retention.

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