Tuberculosis — metabolism and respiration in the absence of growth
Top Cited Papers
- 1 January 2005
- journal article
- review article
- Published by Springer Nature in Nature Reviews Microbiology
- Vol. 3 (1) , 70-80
- https://doi.org/10.1038/nrmicro1065
Abstract
Human tuberculosis is a complex disease caused by bacterial populations that are located in discrete lesions (microenvironments) in a single host. Some of these microenvironments are conducive to replication, whereas others restrict bacterial growth without necessarily sterilizing the infecting microorganisms. The physical and biochemical milieu in these lesions is poorly defined. None of the existing animal models for tuberculosis (except perhaps non-human primates) reproduce the diversity of disease progression that is seen in humans. Nonetheless, transcriptomics and studies using bacterial mutants have led to testable hypotheses about metabolic functions that are essential for viability in the absence of replication. A complete picture of bacterial metabolism must balance reducing equivalents while maintaining an energized membrane and basic cellular processes.Keywords
This publication has 84 references indexed in Scilit:
- The search for new sterilizing anti-tuberculosis drugsFrontiers in Bioscience-Landmark, 2004
- Role of narK2X and narGHJI inHypoxic Upregulation of Nitrate Reduction by MycobacteriumtuberculosisJournal of Bacteriology, 2003
- In Situ Studyof Abundant Expression of Proinflammatory Chemokines and Cytokines inPulmonary Granulomas That Develop in Cynomolgus MacaquesExperimentally Infected withMycobacteriumtuberculosisInfection and Immunity, 2003
- Transcriptional Adaptation of Mycobacterium tuberculosis within MacrophagesThe Journal of Experimental Medicine, 2003
- DNA Alkylation Damage as a Sensor of Nitrosative Stress in Mycobacterium tuberculosisInfection and Immunity, 2003
- Inorganic Polyphosphate: A Molecule of Many FunctionsAnnual Review of Biochemistry, 1999
- Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequenceNature, 1998
- Presence of F420-dependent glucose-6-phosphate dehydrogenase in Mycobacterium and Nocardia species, but absence from Streptomyces and Corynebacterium species and methanogenic ArchaeaFEMS Microbiology Letters, 1997
- THE TREATED PULMONARY LESION AND ITS TUBERCLE BACILLUS III. DRUG SUSCEPTIBILITY STUDIESThe Lancet Healthy Longevity, 1957
- THE TREATED PULMONARY LESION AND ITS TUBERCLE BACILLUS.*The Lancet Healthy Longevity, 1956