Strain variation in Entamoeba histolytica

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Abstract
1. Liver lesions were easily induced in hamsters with two strains of E. histolytica but not with six others.2. Serial liver passage increased the invasiveness to the rat's caecum of one strain which had become attenuated by in vitro cultivation.3. The invasiveness of one of the liver passage substrains was lost a second time after cultivation in vitro and a second series of liver passages restored some degree of virulence.4. Serial liver passage did not increase the invasiveness of two avirulent strains.5. The ease of production of amoebic liver lesions in hamsters is not correlated with invasiveness in the rat's caecum.

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