Prostaglandin/Kinin Activity Related to Changed Renal Compliance after Bumetanide in Dogs

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Abstract
Bumetanide (0.25 mg/kg i.v.) increased kidney volume by 20% at maximal diuresis in anesthetized dogs. The kidney expansion was initially accompanied by a 2- to 4-fold increase in the subcapsular pressure, which was normalized at a time when kidney volume was still considerably increased. Renal blood flow and urinary kinin excretion were enhanced parallel to kidney volume. Renal prostaglandin E activity decreased. The increase in renal blood flow and urinary kinin excretion were inhibited by indomethacin pretreatment. The kinins probably mediated the vascular response of bumetanide. The subcapsular/interstitial pressure might have affected the prostaglandin level of activity after bumetanide while factors related to tubular volume activated the kallikrein-kinin system.