EFFECT OF HYDROCORTISONE ACETATE ON ADULT HUMAN ARTICULAR-CARTILAGE

  • 1 January 1976
    • journal article
    • research article
    • Vol. 3  (4) , 384-389
Abstract
Living adult human articular cartilage were maintained in tissue culture for 8 days. Cartilage explants were cultured in 1 of 3 hydrocortisone acetate concentrations (0.01 .mu.g/ml, 0.01 .mu.g/ml and 1.0 mg/ml) or as control explants without this drug. The amount of proteoglycan released into the medium was measured and no significant difference was found between the explants exposed to the drug and those that were not. Hydrocortisone probably has no catabolic effect on the articular cartilage proteoglycan. Intra-articular corticosteroid injection might not cause cartilage damage.