The Site of Action of Desferrioxamine

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Abstract
Summary. Repeated injections of desferrioxamine significantly depleted the hepatic and splenic iron stores in normal rats, but not in rats which had been hyper‐transfused so as to reduce the rate of release of iron into the plasma. These observations indicate that the storage compounds ferritin and haemosiderin are not important direct donors of iron to desferrioxamine. Since plasma iron is not bound by the chelate, some compound or compounds on the pathway between the stores and the plasma is probably the major immediate source. By differentially labelling the iron in hepatic parenchymal cells and reticulo‐endothelial cells with 59Fe, evidence was obtained that desferrioxamine chelates iron in both cell types.

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