Residence Time of Nisin in the Oral Cavity Following Consumption of Chocolate Milk Containing Nisin

Abstract
The concentration of nisin in saliva was determined at intervals immediately following ingestion of chocolate milk containing approximately 200 Reading Units/ml. This level is 5-10 times the expected usage of nisin. The majority of nisin disappeared from the saliva within 1 min, and no detectable amounts were present 10 min subsequently. Because of the short residence time, the consumption of nisin-containing products would not be expected to cause a change in the bacterial flora of the oral cavity.

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