EFFECTS OF DOSAGE AND TIMING OF ADMINISTRATION OF A PEPTIDE BORONIC ACID INHIBITOR ON LUNG-MECHANICS AND MORPHOMETRICS IN ELASTASE-INDUCED EMPHYSEMA IN HAMSTERS
- 1 April 1986
- journal article
- research article
- Published by Elsevier
- Vol. 133 (4) , 635-638
- https://doi.org/10.1164/arrd.1986.133.4.635
Abstract
The peptide boronic acid, MeOSuc-Ala-Ala-Pro-boroVal-pinacol (AAPbV), is an effective inhibitor of both pancreatic and leukocyte elastase. Initial work showed that AAPbV diminishes the effect of emphysema induced by pancreatic elastase. This initial work has been expanded to show that AAPbV provides a high degree of protection against elastase-induced increases in lung volume and mean linear intercept when given intratracheally at 200 mg/kg either 15 min before, simultaneous with, or 15 min after instilling elastase. Intraperitoneal administration, although less effective, is dose dependent and dependent on the time of treatment. We conclude that a reversible protease inhibitor can be used to prevent aberrant proteolysis in vivo.This publication has 10 references indexed in Scilit:
- A NEW PEPTIDE BORONIC ACID INHIBITOR OF ELASTASE-INDUCED LUNG INJURY IN HAMSTERSPublished by Elsevier ,1986
- Inhibition of the serine proteases leukocyte elastase, pancreatic elastase, cathepsin G, and chymotrypsin by peptide boronic acids.Journal of Biological Chemistry, 1984
- A new class of heterocyclic serine protease inhibitors. Inhibition of human leukocyte elastase, porcine pancreatic elastase, cathepsin G, and bovine chymotrypsin A alpha with substituted benzoxazinones, quinazolines, and anthranilates.Journal of Biological Chemistry, 1982
- A COPPER-DEFICIENT, ZINC-SUPPLEMENTED DIET PRODUCES EMPHYSEMA IN PIGSPublished by Elsevier ,1982
- EFFECTS OF OLIGOPEPTIDE CHLOROMETHYLKETONE ADMINISTERED AFTER ELASTASE - RENAL TOXICITY AND LACK OF PREVENTION OF EXPERIMENTAL EMPHYSEMAPublished by Elsevier ,1981
- THE MODERATION OF ELASTASE-INDUCED EMPHYSEMA IN THE HAMSTER BY INTRA-TRACHEAL PRETREATMENT OR POST-TREATMENT WITH SUCCINYL ALANYL ALANYL PROLYL VALINE CHLOROMETHYL KETONEPublished by Elsevier ,1981
- PREVENTION OF ELASTASE-INDUCED EXPERIMENTAL EMPHYSEMA BY ORAL-ADMINISTRATION OF A SYNTHETIC ELASTASE INHIBITORPublished by Elsevier ,1980
- EFFECT OF THE SPECIFIC ELASTASE INHIBITOR, ALANYL ALANYL PROLYL ALANINE CHLOROMETHYLKETONE, ON ELASTASE-INDUCED EMPHYSEMAPublished by Elsevier ,1980
- Automated measurement of the elastase-inhibitory capacity of plasma with a centrifugal analyzer.Clinical Chemistry, 1979
- A one-year study of the evolution of elastase-induced emphysema in hamstersJournal of Applied Physiology, 1977