Concentration of Three Thrombin Inhibitors in the Nephrotic Syndrome in Adults

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Abstract
Plasma antithrombin III (AT III), α1-antitrypsin (α1-AT) and α1-macroglobulin (α1-M) concentrations were measured in 17 cases of the nephrotic syndrome (NS) in adults. The mean plasma level of AT III was normal. The AT III concentration was correlated with albuminaemia (r=+0.718, p < 0.005), cholesterolaemia (r= – 0.651, p < 0.005) as well as with urinary protein (r = – 0.531, p < 0.05). The α1-AT concentration was decreased (p < 0.01) and correlated with serum albumin level (r = + 0.643, p < 0.01). The α1-M concentration significantly increased (p < 0.001). A negative correlation of the α1-M level with serum albumin concentration (r= -0.561, p < 0.025) and a positive correlation with the cholesterol concentration (r= +0.819, p < 0.001) was found. AT III and α1-M were inversely correlated (r= –0.706, p < 0.005). It is considered that in NS in adults, the increase of α1-M is not compensatory for AT III, and there is no objection to the use of heparin in thrombosis prophylaxis with the exception of a few cases with very low AT III levels.