GLUCOSE INHIBITION OF ASPARTASE SYNTHESIS BY AEROBACTER AEROGENES

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Abstract
Studies were made comparing aspartase synthesis by Aerobacter aerogents grown in the presence and in the absence of glucose, and with or without agitation. It was observed that when a sufficient initial glucose concentration was employed, enzyme synthesis was not resumed to maximum levels even after complete utilization of the sugar. At a lower glucose concentration, however, synthesis did occur, suggesting that the specific repressor metabolite(s) produced from the glucose was not accumulated to inhibitory concentrations after the sugar was metabolized. A difference between stationary and aerobic (shaken) cultures was noted, perhaps affording a suitable system for investigating the molecular mechanism of glucose repression.