Existence and localization of adrenergic neurons in meninges from human adults and fetuses

Abstract
The cerebral and cerebellar pia matter and arachnoid of 90 adults and 15 fetuses were studied to determine whether the number of arachnoidal neural elements is sufficiently high to dismiss the possibility of their being purely heterotopic or displaced structures. With the aid of various histological techniques and formaldehyde (noradrenaline[norepinephrine])-induced fluorescence, the presence of a reticulum composed of many short adrenergic neurons was demonstrated, intimately associated with the sympathetic perivascular innervation. Although this network seems to participate in some aspects of peripheral neuroendocrine function, its possible role in physiologically or pathologically regulating cerebral blood flow is unsettled.