Brain Parenchymal Metabolism of 5-Iodo-2′-Deoxyuridine and 5′-Ester Prodrugs
- 1 January 1992
- journal article
- Published by Springer Nature in Pharmaceutical Research
- Vol. 09 (8) , 1048-1052
- https://doi.org/10.1023/a:1015858512407
Abstract
In an attempt to generate derivatives of 5-iodo-2′-deoxyuridine (IDU) with enhanced blood-brain barrier (BBB) permeability, a series of 5′ ester prodrugs of IDU was synthesized and their metabolism...Keywords
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