Synthesis and DP-IV inhibition of cyano-pyrazoline derivatives as potent anti-diabetic agents
- 19 July 2004
- journal article
- research article
- Published by Elsevier in Bioorganic & Medicinal Chemistry Letters
- Vol. 14 (17) , 4461-4465
- https://doi.org/10.1016/j.bmcl.2004.06.046
Abstract
No abstract availableKeywords
This publication has 25 references indexed in Scilit:
- Aminomethylpyrimidines as novel DPP-IV inhibitors: A 105-fold activity increase by optimization of aromatic substituentsBioorganic & Medicinal Chemistry Letters, 2004
- Diastereoselective synthesis and configuration-dependent activity of (3-substituted-cycloalkyl)glycine pyrrolidides and thiazolidides as dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- Fluoropyrrolidine amides as dipeptidyl peptidase IV inhibitorsBioorganic & Medicinal Chemistry Letters, 2004
- 1-[[(3-Hydroxy-1-adamantyl)amino]acetyl]-2-cyano-(S)-pyrrolidine: A Potent, Selective, and Orally Bioavailable Dipeptidyl Peptidase IV Inhibitor with Antihyperglycemic PropertiesJournal of Medicinal Chemistry, 2003
- Glucagon-Like Peptide-1-(7-36)Amide Is Transformed to Glucagon-Like Peptide-1-(9-36)Amide by Dipeptidyl Peptidase IV in the Capillaries Supplying the L Cells of the Porcine IntestineEndocrinology, 1999
- Improved glucose tolerance in Zucker fatty rats by oral administration of the dipeptidyl peptidase IV inhibitor isoleucine thiazolidideDiabetes, 1998
- Glucagon-like peptidesDiabetes, 1998
- Asymmetric Dipolar Cycloadditions of Me3SiCHN2. Synthesis of a Novel Class of Amino Acids: AzaprolinesJournal of the American Chemical Society, 1997
- Degradation of glucose-dependent insulinotropic polypeptide and truncated glucagon-like peptide 1 in vitro and in vivo by dipeptidyl peptidase IVEndocrinology, 1995
- Dipeptidyl‐peptidase IV hydrolyses gastric inhibitory polypeptide, glucagon‐like peptide‐1(7–36)amide, peptide histidine methionine and is responsible for their degradation in human serumEuropean Journal of Biochemistry, 1993