WATER AND SALT LOADING IN ADRENALECTOMISED DOGS TREATED WITH CORTEXONE, ALDOSTERONE, AND 9α-FLUOROCORTISOL

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Abstract
Oral load-ing tests with water, NaCl, and isotonic saline solution, the last given both orally and intravenously, were performed on normal dogs and on adrenalectomised dogs treated daily with desoxycorticosterone (I) (0.7 mg), aldosterone (II) (0.027 mg), or 9[alpha]-fluorocortisol (III) (0.075-0.1 mg). With none of the 3 steroids was it possible to restore a completely normal pattern of excretion; excretion was delayed and sometimes retention occurred over the 24-hour period following the load. Each of the 3 steroids showed slightly different properties. After a water load (90 ml/kg) the adrenalectomised animals treated with I or III showed an initial delay in excretion but no appreciable retention. II produced the most pronounced delay and the sharpest relative increased Na excretion. After a salt load (0.9-1.0 gAg), the delay in excretion and the retention were greatest in those animals receiving II or III, whereas there was little retention with I despite an initial delay. In all the adrenalectomised animals subjected to a salt load, the Na concentration in the urine was lower than in the normal animal. Loading with an isotonic saline solution (90 ml/kg) produced excretion patterns similar to those seen in response to a solid salt load. The fluid excretion of animals treated with I or HE was poorer than after a water load. An intravenous load of isotonic saline solution (90 ml/kg) was followed by an initial acceleration of excretion, but in animals treated with II or III retention over the 24-hour period was the same as after an oral load. In all experiments hydremia accompanied by an increase in the extracellular fluid occurred. The K concentration in the plasma diminished in proportion to the degree of hydremia. No rise in the K concentration was ever seen but in animals treated with I or III a slight increase in non-protein nitrogen was sometimes recorded despite the hydremia.

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