Recurrent staphylococcal infection in families

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Abstract
This controlled double-blind study examined the efficacy of a single large inoculum of Staphylococcus aureus 502A in interrupting intrafamilial [human] spread of recurrent staphylococcal abscesses. Of 40 families enrolled in the study, 32 completed 6 mo. of follow-up care. All participants were first treated with oral oxacillin sodium or dicloxacillin sodium, twice daily hexachlorophene showers and bacitracin given nasally for 2 wk. Some then received nasal inoculation of 108 to 109 organisms of S. aureus 502A while others were given only sterile broth. Fifteen of 17 families or 29 of 36 individuals who received 502A remained free of recurrence for 6 mo. of observation, while only 4 of 15 control families or 18 of 34 members had no recurrences (P < .005). After 6 mo. after colonization, 83% of the treatment group retained the 502A organism.

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