Observations on Niacin, Riboflavin, Allantoin, Ascorbic Acid, and Vitamin A during Anabolism Induced by Hormones

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Abstract
In adult bitches the excretion of N1-methylnicotinamide decreases markedly during periods of anabolism induced by anterior pituitary growth preparations or testosterone propionate. Coenzymes I and II in the red blood cells do not increase during this apparent storage of niacin. Riboflavin output also decreases following administration of testosterone propionate. Decreases in the excretion of ascorbic acid during similar experiments were significant but less striking; blood ascorbic acid was unchanged. In a single experiment, the concentration of vitamin A in blood fell during the period when testosterone propionate produced its effect. Allantoin excretion remained unchanged in these experiments. The increase in vitamin requirements during normal growth may also be demonstrable during induced growth.