THE EFFECT OF GROWTH HORMONE PREPARATIONS ON ALKALINE PHOSPHATASE OF THE TIBIA

1 August 1949

journal article
research article
Published by The Endocrine Society in Endocrinology

Vol. 45 (2) , 129-134
https://doi.org/10.1210/endo-45-2-129

Abstract

Evidence that anterior pituitary growth hormone stimulates growth of bone is quite extensive. For example, Young (1945) obtained a 6% increase in tibial length by injecting a growth preparation for 60 days into plateaued female rats fed ad lib. Becks, et al. (1946) found that administration of growth hormone to hypophysectomized rats stimulated bone formation, even after a postoperative interval of one year. The width of the proximal epiphyseal cartilage of the tibia of hypophysectomized rats is used to assay the growth hormone (Evans, et al. 1943). Related evidence is the fall in urinary phosphate in dogs (Gaebler and Price, 1937), increase in serum inorganic phosphate in rats (Li, Geschwind, and Evans, 1949), and increase in plasma alkaline phosphatase in rats (Li, Kalman, and Evans, 1947), after growth hormone treatment. Since Robison (1932) established a relationship between bone alkaline phosphatase and bone calcification, and Gomori (1943) confirmed this relationship histochemically,

Keywords

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