The Constant Low Oxygen Concentration in All the Target Cells for Mouse Tail Radionecrosis

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Abstract
When doses of pulsed electrons are delivered in < 4.5 s to the tail of the unanesthetized mouse in air at 19-23.degree. C, there is induced resistance to epithelial necrosis which is characteristic of O2 depletion at high dose rates. The effect is consistent with all the target cells being constantly at .apprx. 3-6 .mu.M O2, rather than with the presence of a transiently or chronically severely hypoxic fraction of target cells. Rediffusion of O2 takes > 4.5 s, and at low doses per pulse the intrapulse dose rate tends to become important. The effect of the natural hypoxia is similar when it is measured immediately after varying priming doses in air and it persists during daily fractionation up to 15 fractions over 3 wk.