BLOOD REGENERATION IN SEVERE ANEMIA

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Abstract
The optimum dose of Fe by mouth in these experiments is about 40 mgm. Fe as metal daily added to the basal ration Fe. Above this level of intake a large excess of Fe salts gives no further rise in the production of hemoglobin. Iron has been given in the form of FeCl3, ferric citrate, FeCO3, FeSO4 and ferrous ammonium sulphate with similar results. The average weekly output of hemoglobin on the optimum Fe salt intake is very close to 25 gm. hemoglobin. The basal ration of bread contains 20 mgm. of Fe as metal per 300 gm. bread as fed. The optimum total intake of Fe exceeds 3-fold the loss of Fe by bleeding and wastage of red cells. Obviously this Fe has some effect in the body other than mere replacement of Fe in lost or worn out hemoglobin. This Fe in excess of hemoglobin Fe requirements obviously exerts some influence upon internal body metabolism so that more hemoglobin is produced. This is probably similar to the effect noted with feeding salt mixtures, Cu and other metals and ash from tissues. Iron is the most potent metal so far tested in severe secondary anemia due to hemorrhage in dogs.

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