KINETICS OF THE REACTIONS TO EXPERIMENTAL-INFECTION IN MICE AFTER OR WITHOUT VACCINATION AGAINST RABIES - STUDY OF ETIO-PATHOGENESIS

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  • 1 January 1979
    • journal article
    • research article
    • Vol. B130  (4) , 485-492
Abstract
When challenged i.m. with the rabies strain CVS, mice treated with cyclophosphamide and then vaccinated died during the 4 days following vaccination in larger numbers and earlier than controls which were treated but not vaccinated. This phenomenon can be transferred, via splenocytes of mice treated with cyclophosphamide and then vaccinated, into syngeneic mice infected 24 h earlier by a large amount of virus (10,000 LD50 by intracerebral route). Mice infected with a small amount of virus (1 LD50 by intracerebral route) can be protected by transferred splenocytes. An immunopathological phenomenon may be involved in experimental rabies of mice, supported by direct or indirect action of T [thymus-derived] lymphocytes against infected target cells.