The expression of 5T4 antigen in colorectal and gastric carcinoma
Open Access
- 1 November 1992
- journal article
- Published by Springer Nature in British Journal of Cancer
- Vol. 66 (5) , 867-869
- https://doi.org/10.1038/bjc.1992.375
Abstract
The expression of 5T4, an oncotrophoblast cell surface antigen was examined in 72 colorectal and 27 gastric carcinomas, with immunoperoxidase technique, on frozen sections. Highly significant association was found between 5T4 expression in the malignant cells and metastatic spread. The results suggest that the appearance of 5T4 molecules in cancer cells reflects a change which may contribute to the development of metastatic potential.Keywords
This publication has 12 references indexed in Scilit:
- Characterization of deoxyguanosine-resistant hypoxanthine-guanine phosphoribosyltransferase− metastatic variants altered in soybean-agglutinin-binding properties and cell-surface glycoproteinsZeitschrift für Krebsforschung und Klinische Onkologie, 1991
- ASSOCIATION OF THE 323/A3 SURFACE GLYCOPROTEIN WITH TUMOR CHARACTERISTICS AND BEHAVIOR IN HUMAN BREAST-CANCER1990
- Isolation and characterization of 5T4, a tumour‐associated antigenInternational Journal of Cancer, 1990
- Immunohistological distribution of 5T4 antigen in normal and malignant tissuesBritish Journal of Cancer, 1990
- Investigation of expression of 5T4 antigen in cervical cancerBritish Journal of Cancer, 1989
- MOLECULAR CHARACTERIZATION OF P2B/LAMP-1, A MAJOR PROTEIN TARGET OF A METASTASIS-ASSOCIATED OLIGOSACCHARIDE STRUCTURE1989
- De novo expression of intercellular-adhesion molecule 1 in melanoma correlates with increased risk of metastasis.Proceedings of the National Academy of Sciences, 1989
- β1-6 Branching of Asn-Linked Oligosaccharides Is Directly Associated with MetastasisScience, 1987
- Expression on cultured human tumour cells of placental trophoblast membrane antigens and placental alkaline phosphatase defined by monoclonal antibodiesInternational Journal of Cancer, 1982
- Differential expression of trophoblast‐specific membrane antigens by normal and abnormal human placentae and by neoplasms of trophoblastic and non‐trophoblastic originInternational Journal of Cancer, 1980