THE EFFECT OF ACTH ON THE ASCORBIC ACID CONCENTRATION OF ADRENAL VENOUS PLASMA OF THE RAT1

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Abstract
The intravenous administration of 20 m/z or 50 m/i of ACTH in hypophysectomized rats or "Stress" in the intact rat produces an increase in the amount and concentration of ascorbic acid in blood collected from the adrenal vein by direct cannulation. Under the in- fluence of ACTH, the amount of ascorbic acid found in adrenal venous blood could account for that which disappeared from the adrenal, but under "stress" more ascorbic acid disappeared from the adrenal than could be found in the adrenal venous blood. The procedure associated with the cannulation of the adrenal vein and the collection of adrenal venous blood caused a large rise in the circulating levels of ascorbic acid even though the pituitary and adrenals had been effectively removed.