Etudes de tolérances oculaire et cutanée chez le lapin de differents echantillons d'esters d'acides gras

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Abstract
A series of tests was carried out on the toxicity of samples of different fatty esters obtained from several manufacturers. Eye irritation tests and skin irritation and sensitization tests were carried out on the rabbit following the official French methods with minor modifications. When tested pure, nearly all the isopropyl and butyl esters used gave some adverse reactions. Only 1 sample (out of 2 tested) of isopropyl stearate appeared to be well tolerated although the primary irritation index on skin was greater than 1. The 2 esters with the greatest adverse skin reactions were isopropyl isostearate and 1 of 2 isopropyl linoleates. Aqueous dispersion (10%) showed considerable diminution of the adverse reactions in the majority of the cases. The results obtained in this paper together with those published previously (27 samples covering 15 different fatty esters), show that worse reactions were obtained with the C8, C12, C14 saturated together with the oleate and linoleate esters. Isopropyl palmitate, stearyl heptonate and arachidyl propionate were the best tolerated as pure materials. Other adverse reactions were obtained with the isopropyl, butyl and octyl stearates and isostearates (except for 1 of 2 isopropyl stearates) and from these results it appears that the alcohol moiety plays little part in irritation when compared with the fatty acid chain. Examination of peroxy values indicates that these have a significant adverse effect for oleates and linoleates.