A variable tandem repeat locus mapped to chromosome band 10q26 is amplified and rearranged in leukocyte DNAs of two cancer patients
- 1 January 1986
- journal article
- Published by Oxford University Press (OUP) in Nucleic Acids Research
- Vol. 14 (20) , 7929-7937
- https://doi.org/10.1093/nar/14.20.7929
Abstract
A highly polymorphic locus associated with the variable tandem repetition of a 35 bp consensus sequence was mapped to chromosome 10, band q26. Examination of leukocyte DNA from a cancer patient revealed the twenty-fold amplification of one allelic fragment of this locus, while the other allelic fragment demonstrated a normal copy number. In another patient, Southern blotting of leukocyte DNA detected the deletion of the 3'-flanking region from one tandem repeat allele. These results indicate that variable tandem repeats may mark highly unstable regions of DNA in the human genome which can be altered by changes more extensive than simple tandem repeat variation.Keywords
This publication has 12 references indexed in Scilit:
- Detection of specific sequences among DNA fragments separated by gel electrophoresisPublished by Elsevier ,2006
- [57] Sequencing end-labeled DNA with base-specific chemical cleavagesPublished by Elsevier ,2004
- Human restriction fragment length polymorphisms and cancer risk assessmentJournal of Cellular Biochemistry, 1986
- Human Luteinizing hormone-releasing hormone gene (LHRH) is located on short arm of chromosome 8 (region 8p11.2 → p21)Somatic Cell and Molecular Genetics, 1986
- Quantitative isolation of DNA restriction fragments from low-melting agarose by Elutip-d affinity chromatographyAnalytical Biochemistry, 1983
- Molecular basis of length polymorphism in the human zeta-globin gene complex.Proceedings of the National Academy of Sciences, 1983
- Complete nucleotide sequences of the T24 human bladder carcinoma oncogene and its normal homologueNature, 1983
- Tumorigenic transformation of mammalian cells induced by a normal human gene homologous to the oncogene of Harvey murine sarcoma virusNature, 1982
- Localization of single copy DNA sequences on G-banded human chromosomes by in situ hybridizationChromosoma, 1981
- The isolation and characterization of linked δ- and β-globin genes from a cloned library of human DNACell, 1978