Presystemic Elimination of Drugs: Theoretical Considerations for Quantifying the Relative Contribution of Gut and Liver
- 1 April 1982
- journal article
- research article
- Published by Elsevier in Journal of Pharmaceutical Sciences
- Vol. 71 (4) , 458-460
- https://doi.org/10.1002/jps.2600710423
Abstract
No abstract availableKeywords
This publication has 13 references indexed in Scilit:
- In vivo assessment of extrahepatic conjugative metabolism in first pass effects using the model compound phenolJournal of Pharmacy and Pharmacology, 1980
- A pharmacokinetic model to differentiate preabsorptive, gut epithelial, and hepatic first-pass metabolismJournal of Pharmacokinetics and Biopharmaceutics, 1979
- Reduction of oral bioavailability of lignocaine by induction of first pass metabolism in epileptic patients.British Journal of Clinical Pharmacology, 1979
- Presystemic Drug EliminationAnnual Review of Pharmacology and Toxicology, 1979
- An isotope clearance method for measurement of liver blood flow during portasystemic shunt in manBritish Journal of Surgery, 1978
- Bioavailability and first‐pass metabolism of oral pentazocine in manClinical Pharmacology & Therapeutics, 1977
- Physiologically Based Pharmacokinetic Model for Digoxin Distribution and Elimination in the RatJournal of Pharmaceutical Sciences, 1977
- Pharmacokinetics of oxprenolol in normal subjectsClinical Pharmacology & Therapeutics, 1976
- First‐pass metabolism of imipramine in manClinical Pharmacology & Therapeutics, 1975
- Lidocaine disposition kinetics in monkey and man; I. Prediction by a perfusion modelClinical Pharmacology & Therapeutics, 1974