Engraftment and Development of Human T and B Cells in Mice After Bone Marrow Transplantation
- 19 April 1991
- journal article
- Published by American Association for the Advancement of Science (AAAS) in Science
- Vol. 252 (5004) , 427-431
- https://doi.org/10.1126/science.1826797
Abstract
A model for human lymphocyte ontogeny has been developed in a normal mouse. Human bone marrow, depleted of mature T and B lymphocytes, and bone marrow from mice with severe combined immunodeficiency were transplanted into lethally irradiated BALB/c mice. Human B and T cells were first detected 2 to 4 months after transplantation and persisted for at least 6 months. Most human thymocytes (30 to 50 percent of total thymocytes) were CD3+CD4+CD8+. Human immunoglobulin was detected in some chimeras, and a human antibody response to dinitrophenol could be generated after primary and secondary immunization.Keywords
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