Some aspects of the metabolism of morphine-N-oxide
- 1 November 1971
- journal article
- Published by Oxford University Press (OUP) in Journal of Pharmacy and Pharmacology
- Vol. 23 (11) , 831-836
- https://doi.org/10.1111/j.2042-7158.1971.tb10199.x
Abstract
After administration of morphine-N-oxide (MNO) to rats the opiates appearing in the urine were morphine (61%) and MNO (39%). After administration of morphine, the urinary opiates were morphine (80%) and normorphine (20%). When tacrine was given with morphine the urine also contained MNO (46% of total urinary opiates) and the amount of normorphine was much decreased (to 1%), the remainder being morphine (53%). Tacrine and amiphenazole inhibited demethylation of morphine and codeine by a rat liver fraction in vitro. MNO had weak inhibitory activity. Neither MNO nor codeine-N-oxide were demethylated in vitro.Keywords
This publication has 9 references indexed in Scilit:
- The analgesic action of morphine‐N‐oxideBritish Journal of Pharmacology, 1968
- A note on the effects of 2, 4-diamino-5-phenylthiazole and 1, 2, 3, 4-tetrahydro-9-aminoacridine on morphine metabolismJournal of Pharmacy and Pharmacology, 1968
- Mass spectrometry of the morphine alkaloidsTetrahedron Letters, 1965
- Formation of an intermediate N-oxide in the oxidative demethylation of N,N-dimethylaniline catalyzed by liver microsomesBiochemical and Biophysical Research Communications, 1964
- The Biosynthesis of Trimethylamine-N-OxideJournal of Biological Chemistry, 1962
- Normorphine, Nalorphine and Morphine. Quantitative Separation and Determination of Small Amounts in Blood and Tissues.Acta Pharmacologica et Toxicologica, 1961
- The metabolism of nicotinamide-N-oxideBiochimica et Biophysica Acta, 1959
- The colorimetric estimation of formaldehyde by means of the Hantzsch reactionBiochemical Journal, 1953
- Einwirkung von Wasserstoffsuperoxyd auf Thebain, Morphin und dessen ÄtherEuropean Journal of Inorganic Chemistry, 1910