Changes Produced by Starvation in the Vitamin Content of Rat Tissues

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Abstract
1. The vitamin Bc pantothenic acid! biotin, riboflavin. pyridosine, and nicotinic acid contents of the livers. kitlneys, and bone marrow have been determined in rats: (a) fed ad libitium; (b) treated TI-ith mustard gas: and (c) whose food intake was restricted. 2. When expressed on the lmis of unit weight of tissue, increase.; of 50 to 180% were noted in the vitamin concentrations of livers from the food-restricted group. Less marked increases occurred in the kidney. while a decrease of 35%; in the vitamin nBc,: content of the bone marrow based on nitrogen content way observed. 3. With the exception of the vitamin Bc, content of the bone marrow. the changes observed in the partially-starved Kroup were also found in the mustard group. 4 Calculations based upon the vitamin content of the liver per 100 g of body weight indicate that both starvation and treatment wth mustard gas cause increases ranging from 1: to 130% in the vitamin Bc, pantothenic acid, biotin, and pyridoxine contents of the liver. No significant changes occur in the riboflavin or nicotinicacid contents.
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