Group‐IV Metal Complexes as Hydroamination Catalysts

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Abstract
During the last 50 years, group‐IV metal complexes have been used extensively as catalysts in organic chemistry. However, a new and rapidly growing field for group‐IV metal catalysis evolved in the 1990s when the groups of Bergman, Livinghouse and Doye found that zirconium and titanium complexes catalyze the inter‐ and intramolecular hydroamination of alkynes and allenes. Starting from early results obtained with zirconocene bis(amides), this review deals mostly with hydroamination reactions based on titanium catalysts. In this context, studies directed towards catalyst development are presented as well as applications of corresponding processes for the synthesis of biologically interesting compounds. However, the Microreview covers group‐IV metal complex catalyzed hydroamination reactions of alkynes and allenes that appeared in the literature before July 31, 2002. (© Wiley‐VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2003)