Cardiovascular and Pulmonary Effects of Aerosolized Prostacyclin Administration in Severe Respiratory Failure Using a Ventilator Nebulization System

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Abstract
We investigated the effects of aerosolized prostacyclin (PGI2) administration on hemodynamics and pulmonary gas exchange in 8 patients with severe respiratory failure and acute pulmonary hypertension. Nebulization of epoprostenol (5 ng/kg body weight for 15 min) decreased mean pulmonary blood pressure from 41.2 ± 6.7 mm Hg (mean ± SD, before administration) to 36.1 ± 6 mm Hg ≤15 min (p