Hepatic Injury in a Child Caused by Trimethoprim-Sulfamethoxazole
- 1 June 1978
- journal article
- research article
- Published by American Academy of Pediatrics (AAP) in Pediatrics
- Vol. 61 (6) , 864-866
- https://doi.org/10.1542/peds.61.6.864
Abstract
Trimethoprim-sulfamethoxazole was given to a 16-year-old boy as prophylaxis for a urinary tract infection. He developed severe cholestatic hepatitis 41 days after administration of the drug. A liver biopsy specimen showed a mixed inflammatory infiltrate in the portal triads and prominent bile stasis. The clinical course in this patient supports the concept of an indirect hypersensitivity reaction to sulfamethoxazole.Keywords
This publication has 3 references indexed in Scilit:
- Prophylactic Efficacy of Nitrofurantoin Macrocrystals and Trimethoprim-Sulfamethoxazole in Urinary InfectionsNew England Journal of Medicine, 1977
- Sulfonamide HepatitisNew England Journal of Medicine, 1966
- Drug-Induced Liver DiseaseArchives of internal medicine (1960), 1965