Influence of Sex on Adrenal Regeneration and Accompanying Hypertension

Abstract
Male rats subjected to right nephrectomy, right adrenalectomy and left adrenal enucleation failed to regenerate adrenal tissue and develop hypertension as observed in the female rat. Testosterone (200 mg/rat/ day) administered to operated female rats inhibited adrenal regeneration of the enucleated adrenal and development of hypertension. It caused a reduction in the blood pressure of ovariectomized, hypertensive, operated female rats. Castration was not effective in promoting adrenal regeneration or hypertension in the male rat.