THE THERAPEUTIC EFFECTIVENESS OF LARGE DOSES OF PALUDRINE IN ACUTE ATTACKS OF SPOROZOITE-INDUCED VIV AX MALARIA (CHESSON STRAIN) 1

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Abstract
The therapeutic effect of paludrine in standardized infections of the Southwest Pacific (Chesson) strain of vivax malaria has been studied in order to compare it with standard suppressive agents and to determine whether or not it exhibits synergistic action with quinine or pentaquine (SN-13,276). Although paludrine failed to prevent relapse in the severely infected individual, it was a valuable drug for the treatment of acute attacks'' of malaria. It had little or no toxicity at doses much higher than the min. necessary to suppress an attack; it did not stain the skin; and it was followed by a latent period longer than that after quin-acrine (atabrine). Its prolongation of the subsequent latent period, however, was considerably less than that of chloro-quine (SN-7618). Concurrent admn. of paludrine and quinine did not enhance the value of either in the treatment of malaria. There was a marked increase in the plasma concn. of pentaquine when it was administered concurrently with paludrine, but no evidence of synergistic activity was found.