Transient Impaired Cell‐Mediated Tumor Immunity after Acute Infection with Lymphocytic Choriomeningitis Virus

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Abstract
Intraperitoneal injection of nononcogenic lymphocytic choriomeningitis (LCM) virus in adult C3H mice causes a symptomless infection but stimulates specific cell‐mediated and humoral immune responses. However, median survival time of virus‐infected mice inoculated with syngeneic tumor cells was significantly shortened, and growth of semiallogeneic tumors was significantly enhanced. Cell‐mediated cytotoxicity measured as chromium‐51 release from labeled tumor cells was significantly suppressed but was recovered within 55 days after infection. The suppressed immune responsiveness could be conferred on a normal spleen cell population when activated in virus‐infected recipients. Chronically LCM virus‐infected mice showed an unimpaired cell‐mediated immune response to tumor allografts.