Comparison of the radioisotope dilution-coated charcoal method and a microbiological method (L. leichmannii) for measuring vitamin B12 in serum

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Abstract
A comparison has been made of the radioisotope dilution-coated charcoal method and a microbiological assay (with L. leichmannii as test organism) for determining the concentration of vitamin B12 inserum. A satisfactory correlation was found between the results of the 2 methods. Under appropriate conditions the reproducibility of the radioisotope method compared favorably with that of the microbiological method.